The king of genetic sequencing

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Original e-book date: April 18, 2019

DNA sequencing, or gene sequencing, is a way of determining the choices nucleic acid sequences in DNA. DNA is made of four nucleotides, adenine (A), thymine (T), cytosine (C) and guanine (G). In the double-helix structure of the DNA molecule, A constantly pairs with T and C continually pairs with G. These code for the proteins of all dwelling matters, including humans.

The gene sequencing industry has surely taken off within the years because the Human Genome Project’s difficult draft was introduced in June 2000. Shortly after the projected become finished, the choices enterprise changed into challenged to increase a method to sequence an individual’s genome for $1,000. As an example of the way some distance this has come, in 2007, biotech corporation Knome provided the choices first direct-to-purchaser genome sequencing services at $350,000. In 2010, Illumina supplied individual genome sequencing to customers at an initial charge of $50,000 in line with individual.

Although there is a few capability argument about precisely which organisation first produced a whole genome series for beneath $1,000, Illumina become typically given that credit in 2014 for its HiSeq X10 gadget, although to begin with, the fee of the instrument itself ran approximately $1 million (if you bought 10). Life Technologies is now and again credited for its Ion Proton Sequencer and Veritas Genetics changed into presenting collection evaluation for about $1,000.

Regardless, it’s a booming enterprise, with gene sequencing turn out to be an indispensable manner in many regions of medical diagnostics and is the number one generation underpinning the burgeoning area of liquid biopsy assessments. Now the race is on to power the choices value down to $100 or even decrease.

Here’s a take a look at the top 10 gene sequencing groups by using revenue.

#1. Illumina. Headquartered in San Diego, Illumina said sales of $3.333 billion in 2018. Its leader government officer, Francis deSouza, informed analysts at the choices JP Morgan 37th Healthcare Conference that it expects to get the cost of sequencing down to $a hundred. In March 2019, Illumina and the Lundbeck Foundation GeoGenetics Centre at the choices University of Copenhagen, Denmark, partnered to look at the choices dating among neurological and mental issues and infectious pathogens.

#2. Thermo Fisher Scientific. Based in Waltham, Mass., Thermo Fisher’s recognition on gene sequencing is a extraordinarily small percentage of its ordinary sales, or about 2%. In 2018, that represented approximately $418.36 million. And in January 2018, the choices enterprise released a benchtop product line for next-generation sequencing (NGS), the choices Ion GeneStudio S5 Series. NGS falls interior its existence sciences solutions phase, which in 2018 made up $6.269 billion of its total sales of $24.358 billion.

#three. BGI Genomics. Located in Shenzhen, Guangdong, China, the agency become shaped in 1999 to participate in the Human Genome Project. The enterprise hasn’t stated complete-year 2018 revenue but (it is scheduled for April 25), however its maximum current four quarters indicated 18% increase from the choices $311.607 million reported in 2017. It is the choices top genetic checking out enterprise in China. On March 11, 2019, the choices company announced plans to commercialize Natera’s Signatera molecular residual disorder (MRD) test in China.

#4. Agilent Technologies. Headquartered in Santa Clara, Calif., Agilent is a frontrunner in laboratory device, together with NGS. In 2018, it indicated about $250 million in annual revenues related to the choices NGS merchandise. That money owed for 26.five% of the $943 million in 2018 sales its diagnostics and genomics institution (DGG) stated. In the February 20, 2019, first-area monetary record, chief government officer Mike McMullen told analysts, “Our NGS-associated commercial enterprise again grew double digits in this sector.”

#five. 10X Genomics. Based in Pleasanton, Calif., 10x stated $146 million in sales in 2018. In December 2018, the choices organisation obtained Stockholm-based totally Spatial Transcriptomics, a leader inside the area of spatial genomics. The corporation has also received Epinomics in August 2018, which specializes in epigenetics, and introduced a brand new line of merchandise.

#6. QIAGEN. Headquartered in Hilden, Germany, QIAGEN gives sample and assay technologies for molecular diagnostics, applied trying out, and educational and pharmaceutical studies. It operates extra than 35 workplaces in over 25 international locations. On April 12, the organisation released its novel therascreen FGFR RGQ RT-PCR Kit inside the U.S. as a accomplice diagnostic for Janssen Biotech’s Balversa (erdafitinib). Janssen is a Johnson & Johnson organization. In 2018, QIAGEN’s NGS income have been $a hundred and forty million, projected to hit $one hundred ninety million this year.

#7. GENEWIZ (Brooks Automation). Located in South Plainfield, NJ, the choices enterprise turned into acquired in November 2018 by way of Brooks Automation, a worldwide chief of automation and cryogenic solutions for existence sciences and semiconductor production. The corporation’s first-sector 2019 financials show that GENEWIZ has generated $33 million within the region, with $16 million beneath Brooks possession. That’s approximately a 20% 12 months-over-year boom, with 30% by means of NGS and 15% by means of Sanger sequencing growth.

#eight. MACROGEN. Macrogen is a South Korean organization with U.S. headquarters in Rockville, Md. In 2018 it introduced in $97.066 million in sales. More importantly, with the aid of the choices stop of 2018, it became authorised by the choices Clinical Laboratory Improvement Amendments (CLIA) for its NGS medical labs in Seoul, South Korea, and at Bundang Precision Medicine Center. They are the first Korean scientific laboratories to obtain CLIA accreditation, which lets in them to carry out clinical laboratory trying out within the U.S. In a December 20, 2018 assertion, Kap-Seok Yang, the choices corporation’s leader executive officer, stated, “This gives us a bonus in constructing genome huge records with clinical establishments for the duration of the arena.”

#9. Pacific Biosciences of California (PacBio). Based in Menlo Park, Calif., PacBio turned into founded in 2004. It develops and manufactures gene sequencing systems. In November 2018, Illumina received PacBio for $1.2 billion. On April 2, 2019, the agency introduced a retrospective study with scientists at the Anthony Nolan Research Institute in the UK tested that extremely-high-decision HLA typing the usage of PacBio sequencing identified more potent fits related to progressed survival prices amongst sufferers receiving hematopoietic mobile transplants. PacBio said $seventy eight.626 million in revenues in 2018, which turned into clearly approximately a sixteen% drop from the previous yr.

#10. Oxford Nanopore Technologies. Headquartered in, accurately sufficient, Oxford, UK, Oxford Nanopore reported $18.1 million in revenues in 2017. In 2018 it stated financing rounds, $sixty five.6 million in October and $131.2 million in March. On April sixteen, the choices corporation announced that its PromethION 38 (P48) device accomplished 7 Terabases in a single test. It was part of an inner software to validate the brand new system in advance of delivery to early users in May. External customers will try to mirror the results.